Indian Journal of Science and Research

Title: EFFECT OF POLYHERBAL FORMULATIONS MEF-4 AND MEF-8 ON HIGH FAT DIET INDUCED OBESITY IN SD RATS
Author: Niraj Kumar Sharma
Keyword: High fat diet, Hyperlipidemia, Lipid profile, Polyherbal formulation
Page No: 01-05

Abstract: Historically, plants have provided a source of inspiration for novel drug compounds, as plant derived medicine have made large contribution to human health and well-being. In this study, two polyherba l formulations (MEF-4 and MEF-8) were prepared using methanolic extracts of two medicinal plants such as Camelia sinensis and Citrus Aurantium. The present study is undertaken to evaluate Anti-obesity potentials through in-vivo high fat diet induced obesity of the polyherbal formulations prepared in-house. The rats were fed with high fat diet for the induction of hyperlipidemia for two weeks. Upon confirmation of disease induction the animal experiments were conducted as per standard protocols. The hyperlipidemic rats were administered with both the formulation at a dose of 250 mg/kg and the control groups received standard diet & high fat diet orally for 30 days. After treatment for 30 days, blood samples from the MEF-4/MEF-8/standard/vehicle were collected and effect on body weight, hematology and lipid profile was determined. The formulations MEF-4 and MEF-8 was associated with a significant (p<0.01) decline in total cholesterol (20-22%), LDL (48-52%), triglyceride (36-40%) and phospholipids (24-27%) respectively. It was also observed that the formulation MEF-4 was more effective than MEF-8 at the same dose.Download PDF

Title: EFFECT OF POLYHERBAL FORMULATIONS MEF-4 AND MEF-8 ON HIGH FAT DIET INDUCED OBESITY IN SD RATS
Author: Niraj Kumar Sharma
Keyword: High fat diet, Hyperlipidemia, Lipid profile, Polyherbal formulation
Page No: 01-05

Abstract: Historically, plants have provided a source of inspiration for novel drug compounds, as plant derived medicine have made large contribution to human health and well-being. In this study, two polyherba l formulations (MEF-4 and MEF-8) were prepared using methanolic extracts of two medicinal plants such as Camelia sinensis and Citrus Aurantium. The present study is undertaken to evaluate Anti-obesity potentials through in-vivo high fat diet induced obesity of the polyherbal formulations prepared in-house. The rats were fed with high fat diet for the induction of hyperlipidemia for two weeks. Upon confirmation of disease induction the animal experiments were conducted as per standard protocols. The hyperlipidemic rats were administered with both the formulation at a dose of 250 mg/kg and the control groups received standard diet & high fat diet orally for 30 days. After treatment for 30 days, blood samples from the MEF-4/MEF-8/standard/vehicle were collected and effect on body weight, hematology and lipid profile was determined. The formulations MEF-4 and MEF-8 was associated with a significant (p<0.01) decline in total cholesterol (20-22%), LDL (48-52%), triglyceride (36-40%) and phospholipids (24-27%) respectively. It was also observed that the formulation MEF-4 was more effective than MEF-8 at the same dose.Download PDF

Title: MIASMATIC THEORIES- CENTRAL DOGMA FOR HOMEOPATHIC PRACTICE
Author: Princee Sharma, Jitendra Jain, Shahzad Lirani, Meeta Nilhani, Shailendra Tamrakar, Deepak Kumar Dash, Vaibhav Tripathi
Keyword: Miasm, Source of illness, Epigenetics, Minimal comprehension
Page No: 06-09

Abstract: Samuel Hahnemann's hypothesis of miasms namely psora, sycosis and syphillis has customarily been connected to the three illnesses of scabies, gonorrhea, and syphilis. However, miasms have positive inf luence on human life as well which we quite often disregard; the miasms help humankind in exploring its full potential. There is not anything negative with regards to them fundamentally. Investigating the origin source of illnesses and the connection and purpose for the related miasms should be put high on the treatment plan during clinical practice with the help of current research findings on epigenetics. Over the most recent 20 years, an astounding difference in assessment has happened in the homeopathic practice in regards to miasms. Homeopaths use miasmatic models regularly during patient counseling. Practitioners who do not work miasmatically are frequently met with minimal comprehension by the individuals who do. It is time we looked again at these three miasms to give them an important and present-day evaluation. In this review work, we have attempted to incorporate shallow data about the miasm and famous miasmatic speculations of eminent homeopaths of Indian origin alongside the classical miasmatic hypothesis.Download PDF

Title: MIASMATIC THEORIES- CENTRAL DOGMA FOR HOMEOPATHIC PRACTICE
Author: Princee Sharma, Jitendra Jain, Shahzad Lirani, Meeta Nilhani, Shailendra Tamrakar, Deepak Kumar Dash, Vaibhav Tripathi
Keyword: Miasm, Source of illness, Epigenetics, Minimal comprehension
Page No: 06-09

Abstract: Samuel Hahnemann's hypothesis of miasms namely psora, sycosis and syphillis has customarily been connected to the three illnesses of scabies, gonorrhea, and syphilis. However, miasms have positive inf luence on human life as well which we quite often disregard; the miasms help humankind in exploring its full potential. There is not anything negative with regards to them fundamentally. Investigating the origin source of illnesses and the connection and purpose for the related miasms should be put high on the treatment plan during clinical practice with the help of current research findings on epigenetics. Over the most recent 20 years, an astounding difference in assessment has happened in the homeopathic practice in regards to miasms. Homeopaths use miasmatic models regularly during patient counseling. Practitioners who do not work miasmatically are frequently met with minimal comprehension by the individuals who do. It is time we looked again at these three miasms to give them an important and present-day evaluation. In this review work, we have attempted to incorporate shallow data about the miasm and famous miasmatic speculations of eminent homeopaths of Indian origin alongside the classical miasmatic hypothesis.Download PDF

Title: LIFESTYLE DISORDERS AND THEIR MANAGEMENT: A SHORT REVIEW
Author: Md Sadique Hussain1, Ganesh N. Sharma*, Sakshi Sharma
Keyword: - Lifestyle disorders; Health; Poor lifestyle; Diet; Physical activity
Page No: 10-15

Abstract: Lifestyle has long been related to the advancement of various chronic illnesses. In the present era of developed technology, communication, and electronic gadgets, the level of comforts available for our utility has increased but it has somehow or other also led to an increase in our problems associated with psychosomatic and spiritual health. The concept of lifestyle disease is used for several different diseases such as asthma, coronary heart disease, diabetes, lung cancer, etc. The idea shows that diseases are caused by a person’s behaviors. The transformation from an ancestral to a new-fashioned way of living, eating diets high in fat and calories combined with an increased level of mental stress has intensified the problem further. A change in eating habits & the embracement of an inactive lifestyle has led to the increasing influence of lifestyle diseases like Obesity, Asthma, Diabetes, Arthritis, Hypertension, Chronic liver diseases, Coronary heart disease, Metabolic syndrome, Depression, and Cancer, all across the globe. A Combined made report by the World Health Organization and the World Economic Forum, tells that India will face a loss of $236.6 billion approximately by 2015 on account of a sick way of life and unhealthy diet. Poor lifestyle includes unhealthy food, decreasing physical activity, increased tobacco consumption, high intake of alcohol, inadequate sleep, and stress due to increased work pressure.Download PDF

Title: LIFESTYLE DISORDERS AND THEIR MANAGEMENT: A SHORT REVIEW
Author: Md Sadique Hussain1, Ganesh N. Sharma*, Sakshi Sharma
Keyword: - Lifestyle disorders; Health; Poor lifestyle; Diet; Physical activity
Page No: 10-15

Abstract: Lifestyle has long been related to the advancement of various chronic illnesses. In the present era of developed technology, communication, and electronic gadgets, the level of comforts available for our utility has increased but it has somehow or other also led to an increase in our problems associated with psychosomatic and spiritual health. The concept of lifestyle disease is used for several different diseases such as asthma, coronary heart disease, diabetes, lung cancer, etc. The idea shows that diseases are caused by a person’s behaviors. The transformation from an ancestral to a new-fashioned way of living, eating diets high in fat and calories combined with an increased level of mental stress has intensified the problem further. A change in eating habits & the embracement of an inactive lifestyle has led to the increasing influence of lifestyle diseases like Obesity, Asthma, Diabetes, Arthritis, Hypertension, Chronic liver diseases, Coronary heart disease, Metabolic syndrome, Depression, and Cancer, all across the globe. A Combined made report by the World Health Organization and the World Economic Forum, tells that India will face a loss of $236.6 billion approximately by 2015 on account of a sick way of life and unhealthy diet. Poor lifestyle includes unhealthy food, decreasing physical activity, increased tobacco consumption, high intake of alcohol, inadequate sleep, and stress due to increased work pressure.Download PDF

Title: HEPATOPROTECTIVE ACTIVITY OF ALOE VERA EXTRACT IN RODENT MODEL
Author: Hari Mohan*, Virendra Kumar Sharma and Steffi Thomas
Keyword: Aloe-vera, Hepato-protective, Rodent Model, Paracetamol.
Page No: 16-21

Abstract: Present study was designed to evaluate Hepatoprotective Activity of Aloe Vera Extract in Rodent Model. The organoleptic characters of alcoholic extract of Aloe vera leaf extract were found to be dark green in colour, semi solid, and taste is acrid. alcoholic extract was observed to be dissolved in water and DMSO. Preliminary phyto-chemicals test was done on the alcoholic extract of Aloe vera leaf and it is found to be rich in Carbohydrates, Proteins, Saponin, Flavonoids and Phenolic compound. Acute oral toxicity of plant extract was performed to check the toxicity of plant and extract was found to be non toxic up to the dose of 2000 mg/kg. For the determination of protective effect of Aloe vera leaf extract against paracetamol induced Hepato-toxicity, firstly level of GSH and SOD was checked. GSH and SOD level was tested in vehicle treated group after that Paracetamol treated group and then 200mg/kg of plant extract along with Paracetamol treated group and after that 400mg/kg of plant extract along with Paracetamol treated group. In-vivo antioxidant activity was measured through a set of enzymes including SGOT, SGPT, and ALP. The extract administered at dose 400 mg/kg showed better activity. Download PDF

Title: HEPATOPROTECTIVE ACTIVITY OF ALOE VERA EXTRACT IN RODENT MODEL
Author: Hari Mohan*, Virendra Kumar Sharma and Steffi Thomas
Keyword: Aloe-vera, Hepato-protective, Rodent Model, Paracetamol.
Page No: 16-21

Abstract: Present study was designed to evaluate Hepatoprotective Activity of Aloe Vera Extract in Rodent Model. The organoleptic characters of alcoholic extract of Aloe vera leaf extract were found to be dark green in colour, semi solid, and taste is acrid. alcoholic extract was observed to be dissolved in water and DMSO. Preliminary phyto-chemicals test was done on the alcoholic extract of Aloe vera leaf and it is found to be rich in Carbohydrates, Proteins, Saponin, Flavonoids and Phenolic compound. Acute oral toxicity of plant extract was performed to check the toxicity of plant and extract was found to be non toxic up to the dose of 2000 mg/kg. For the determination of protective effect of Aloe vera leaf extract against paracetamol induced Hepato-toxicity, firstly level of GSH and SOD was checked. GSH and SOD level was tested in vehicle treated group after that Paracetamol treated group and then 200mg/kg of plant extract along with Paracetamol treated group and after that 400mg/kg of plant extract along with Paracetamol treated group. In-vivo antioxidant activity was measured through a set of enzymes including SGOT, SGPT, and ALP. The extract administered at dose 400 mg/kg showed better activity. Download PDF

Title: CORRELATION MODELS TO DETERMINE THE CHARACTERISTICS OF CONCRETE WITH PLASTIC GRANULES
Author: Tejas Patil, Dr. M.P. Verma, Dr Sanjeev Kumar Verma
Keyword: Concrete; aggregates; plastic; characteristics; strength
Page No: 22-24

Abstract: To test the viability, mathematical models have been constructed, compressive strength and split tensile strength of the concrete samples produced using plastic granules as replacement of coarse aggre gates. In this study, discarded Low Density Polyethylene granules were used as a partial replacement for coarse aggregate Its influence on the properties of concrete has been studied. Waste LDPE is utilised as a partial substitute for coarse aggregates in various quantities such as 0%, 20%, 30%, and 40%.Download PDF

Title: CORRELATION MODELS TO DETERMINE THE CHARACTERISTICS OF CONCRETE WITH PLASTIC GRANULES
Author: Tejas Patil, Dr. M.P. Verma, Dr Sanjeev Kumar Verma
Keyword: Concrete; aggregates; plastic; characteristics; strength
Page No: 22-24

Abstract: To test the viability, mathematical models have been constructed, compressive strength and split tensile strength of the concrete samples produced using plastic granules as replacement of coarse aggre gates. In this study, discarded Low Density Polyethylene granules were used as a partial replacement for coarse aggregate Its influence on the properties of concrete has been studied. Waste LDPE is utilised as a partial substitute for coarse aggregates in various quantities such as 0%, 20%, 30%, and 40%.Download PDF

	Fast reviewing process: Adopting the fast reviewing process we communicate with authors at all stages till publication. Proactive teams of reviewers from National and International front help us to complete the process within the time.
	IJSR dose not impose any publication fee or processing charges.
	Fast reviewing process: Adopting the fast reviewing process we communicate with authors at all stages till publication. Proactive teams of reviewers from National and International front help us to complete the process within the time.
	IJSR dose not impose any publication fee or processing charges.