Indian Journal of Science and Research

Title: RECENT ADVANCES IN CHEMOTHERAPY OF LUNG CANCER USING NOVEL DRUG DELIVERY SYSTEM EFFECT
Author: Lokendra Singh Thakur, Kuneeta Ahirwar, Mahima Jain, Amit Choudhary, Mr. Pushpendra Kumar Khangar
Keyword: - Nanocarrier technologies, Lung Cancer, Treatment
Page No: 25-31

Abstract: Cancer is one of the most common diseases that results in a large number of fatalities worldwide. Lung cancer is the most chronic type of cancer in the world, according to the major types of cancer. L ung cancer is typically treated with a combination of medical procedures such as chemotherapy, surgical removal, and radiation therapy. Nanocarrier technologies are currently being employed widely to exploit and overcome the blockages caused by lung cancer. Because the goal of nano-carrier-loaded therapeutic drug delivery systems is to inhibit the proliferation of tumour cells, they have showed promise in treating lung cancer. Various techniques of nano drug delivery, such as liposomes, dendrimers, quantum dots, carbon nanotubes, and metallic nanoparticles, are reviewed in this review. Nano-carrier drug delivery systems appear to be a promising strategy, and as a result, fresh and more advanced paths in cancer therapies are predicted to open up. Keywords: - Nanocarrier technologies, Lung Cancer, Treatment. Download PDF

Title: RECENT ADVANCES IN CHEMOTHERAPY OF LUNG CANCER USING NOVEL DRUG DELIVERY SYSTEM EFFECT
Author: Lokendra Singh Thakur, Kuneeta Ahirwar, Mahima Jain, Amit Choudhary, Mr. Pushpendra Kumar Khangar
Keyword: - Nanocarrier technologies, Lung Cancer, Treatment
Page No: 25-31

Abstract: Cancer is one of the most common diseases that results in a large number of fatalities worldwide. Lung cancer is the most chronic type of cancer in the world, according to the major types of cancer. L ung cancer is typically treated with a combination of medical procedures such as chemotherapy, surgical removal, and radiation therapy. Nanocarrier technologies are currently being employed widely to exploit and overcome the blockages caused by lung cancer. Because the goal of nano-carrier-loaded therapeutic drug delivery systems is to inhibit the proliferation of tumour cells, they have showed promise in treating lung cancer. Various techniques of nano drug delivery, such as liposomes, dendrimers, quantum dots, carbon nanotubes, and metallic nanoparticles, are reviewed in this review. Nano-carrier drug delivery systems appear to be a promising strategy, and as a result, fresh and more advanced paths in cancer therapies are predicted to open up. Keywords: - Nanocarrier technologies, Lung Cancer, Treatment. Download PDF

Title: CURRANT REVIEW ON SYNTHESIS OF PRODRUG AND ITS APPLICATION
Author: Yash Jain, Hiteshi Jain, Yash Soni, Palak Jain, Mr. Imran Khan
Keyword: Prodrug, Synthesis, Application, Review
Page No: 38-43

Abstract: Prodrug design is a well-known molecular modification method that tries to increase the solubility and pharmacokinetic aspects of medications while lowering their toxicity by optimising their physicoc hemical and pharmacological properties. Carrier would alter the physical properties of a medicine in order to boost its fat or water solubility or to enable site-directed delivery. Despite the fact that multiple studies on diverse prodrugs have been conducted, there have been surprisingly few reviews on different carriers that can be employed for prodrug synthesis published too far. One of the most significant roadblocks to drug development is a lack of solubility. The goal of this review is to describe current developments and application of prodrug approach. The primary chemical carriers will be reviewed, as well as instances of effective techniques, with an emphasis on the field's progress in the last ten years. Key words: Prodrug, Synthesis, Application, Review Download PDF

Title: CURRANT REVIEW ON SYNTHESIS OF PRODRUG AND ITS APPLICATION
Author: Yash Jain, Hiteshi Jain, Yash Soni, Palak Jain, Mr. Imran Khan
Keyword: Prodrug, Synthesis, Application, Review
Page No: 38-43

Abstract: Prodrug design is a well-known molecular modification method that tries to increase the solubility and pharmacokinetic aspects of medications while lowering their toxicity by optimising their physicoc hemical and pharmacological properties. Carrier would alter the physical properties of a medicine in order to boost its fat or water solubility or to enable site-directed delivery. Despite the fact that multiple studies on diverse prodrugs have been conducted, there have been surprisingly few reviews on different carriers that can be employed for prodrug synthesis published too far. One of the most significant roadblocks to drug development is a lack of solubility. The goal of this review is to describe current developments and application of prodrug approach. The primary chemical carriers will be reviewed, as well as instances of effective techniques, with an emphasis on the field's progress in the last ten years. Key words: Prodrug, Synthesis, Application, Review Download PDF

Title: REVIEW ON HYPOGLYCEMIC PROPERTIES OF MEDICINAL PLANTS FOR TREATMENT OF DIABETES
Author: Nikhil Sahu, Nitin Nema, Neetesh, Prateek Jain, Mrs. Shikha Mishra
Keyword: Diabetes, Herbal treatment, Review, Hypoglycemic properties
Page No: 44-52

Abstract: Diabetes is a significant metabolic illness that is treated with a variety of medicinal herbs in traditional medicine. Many present treatments are derived from these plants, which have no negative eff ects. According to the World Health Organization, up to 90% of people in underdeveloped countries use traditional medicine (plants and their products) for primary health care. Approximately 800 plants have been identified to have anti-diabetic properties.The goal of this systematic review is to look at diabetes and summaries the many therapies for it, with an emphasis on herbal therapy. Key words: Diabetes, Herbal treatment, Review, Hypoglycemic properties Download PDF

Title: REVIEW ON HYPOGLYCEMIC PROPERTIES OF MEDICINAL PLANTS FOR TREATMENT OF DIABETES
Author: Nikhil Sahu, Nitin Nema, Neetesh, Prateek Jain, Mrs. Shikha Mishra
Keyword: Diabetes, Herbal treatment, Review, Hypoglycemic properties
Page No: 44-52

Abstract: Diabetes is a significant metabolic illness that is treated with a variety of medicinal herbs in traditional medicine. Many present treatments are derived from these plants, which have no negative eff ects. According to the World Health Organization, up to 90% of people in underdeveloped countries use traditional medicine (plants and their products) for primary health care. Approximately 800 plants have been identified to have anti-diabetic properties.The goal of this systematic review is to look at diabetes and summaries the many therapies for it, with an emphasis on herbal therapy. Key words: Diabetes, Herbal treatment, Review, Hypoglycemic properties Download PDF

Title: REVIEW ON SYNTHESIS SCHEMES OF FIRST LINE DRUGS OF ANTITUBERCULAR DRUGS
Author: Vishal Sahu, Vishal Kushwaha, Vijay Sahu, Satyam Shukla, Mr. Imran Khan
Keyword: Antitubercular, Synthesis Schemes, Review
Page No: 53-59

Abstract: Tuberculosis (TB) is an infectious disease caused by a variety of mycobacterium strains, the most prevalent of which being Mycobacterium tuberculosis. M. tuberculosis, M. africanum, M. bovis, and the Bacillus Calmette-Guérin strain, M. microti, M. canettii, M. caprae, M. pinnipedii, and M. mungi are all members of the M. tuberculosis complex. Other than M. tuberculosis complex, other species (M. avium complex, M. gordonae, M. kansasii, M. simiae, M. chelonae, M. fortuitum, etc.) do not cause tuberculosis in humans. TB mainly affects the lungs but can also affect other regions of the body. For many years, it was thought to be a poverty disease due to its rarity in developed countries. The present review focus on some synthesis schemes of first line drugs of antitubercular drugs. Key words: Antitubercular, Synthesis Schemes, Review Download PDF

Title: REVIEW ON SYNTHESIS SCHEMES OF FIRST LINE DRUGS OF ANTITUBERCULAR DRUGS
Author: Vishal Sahu, Vishal Kushwaha, Vijay Sahu, Satyam Shukla, Mr. Imran Khan
Keyword: Antitubercular, Synthesis Schemes, Review
Page No: 53-59

Abstract: Tuberculosis (TB) is an infectious disease caused by a variety of mycobacterium strains, the most prevalent of which being Mycobacterium tuberculosis. M. tuberculosis, M. africanum, M. bovis, and the Bacillus Calmette-Guérin strain, M. microti, M. canettii, M. caprae, M. pinnipedii, and M. mungi are all members of the M. tuberculosis complex. Other than M. tuberculosis complex, other species (M. avium complex, M. gordonae, M. kansasii, M. simiae, M. chelonae, M. fortuitum, etc.) do not cause tuberculosis in humans. TB mainly affects the lungs but can also affect other regions of the body. For many years, it was thought to be a poverty disease due to its rarity in developed countries. The present review focus on some synthesis schemes of first line drugs of antitubercular drugs. Key words: Antitubercular, Synthesis Schemes, Review Download PDF

Title: FORMULATION DEVELOPMENT AND EVALUATION OF ETODOLAC EMULGEL WITH NATURAL PENETRATION ENHANCER
Author: Ravi Gour, Pushpendra Kumar Khangar*, Dr. Vivek Jain, Dr. Sunil Kumar Jain
Keyword: Etodolac, Emulgel, Piperine, Capsaicin, Formulation, Evaluation
Page No: 60-66

Abstract: The purpose of this research was to prepare etodolac loaded emulsion for sustained release of drug and incorporate it in to topical gel delivery system to reduce the side effects by site specific targ eting. The present work focused on the formulation of etodolac emulgel and the effect of natural permeation enhancers such as piperine and capsaicin. Etodolac emulgel was prepared by emulgel method by using various excipients such as polymers as carbopol-940, propylene glycol, tween20, and span20 and with penetration enhancers such as piperine and capsaicin. The prepared emulgel was evaluated for its properties Further the analysis of release mechanism was carried out by fitting the drug release data to various kinetic equations like zero order, first order, higuchi’s and korssmeyer peppas equations and from the values so obtained, the best fit model were arrived at. From the above results formulation F4 was found to be best formulation for the topical release of etodolac that complied with all the parameters. It releases 73.79±0.98 % of drug in 8 h time. It follows the higuchi’s of drug release kinetics. Also, stability upon storage for 3 month at room temperature, where no significant change was observed in the parameters evaluated like color, consistency, pH, rheological properties, skin permeability and drug release pattern. Therefore, it was concluded that etodolac emulgel formula could be very promising topical alternative for the conventional dosage form provide sustained and prolonged delivery of drug. Key words: Etodolac, Emulgel, Piperine, Capsaicin, Formulation, Evaluation Download PDF

Title: FORMULATION DEVELOPMENT AND EVALUATION OF ETODOLAC EMULGEL WITH NATURAL PENETRATION ENHANCER
Author: Ravi Gour, Pushpendra Kumar Khangar*, Dr. Vivek Jain, Dr. Sunil Kumar Jain
Keyword: Etodolac, Emulgel, Piperine, Capsaicin, Formulation, Evaluation
Page No: 60-66

Abstract: The purpose of this research was to prepare etodolac loaded emulsion for sustained release of drug and incorporate it in to topical gel delivery system to reduce the side effects by site specific targ eting. The present work focused on the formulation of etodolac emulgel and the effect of natural permeation enhancers such as piperine and capsaicin. Etodolac emulgel was prepared by emulgel method by using various excipients such as polymers as carbopol-940, propylene glycol, tween20, and span20 and with penetration enhancers such as piperine and capsaicin. The prepared emulgel was evaluated for its properties Further the analysis of release mechanism was carried out by fitting the drug release data to various kinetic equations like zero order, first order, higuchi’s and korssmeyer peppas equations and from the values so obtained, the best fit model were arrived at. From the above results formulation F4 was found to be best formulation for the topical release of etodolac that complied with all the parameters. It releases 73.79±0.98 % of drug in 8 h time. It follows the higuchi’s of drug release kinetics. Also, stability upon storage for 3 month at room temperature, where no significant change was observed in the parameters evaluated like color, consistency, pH, rheological properties, skin permeability and drug release pattern. Therefore, it was concluded that etodolac emulgel formula could be very promising topical alternative for the conventional dosage form provide sustained and prolonged delivery of drug. Key words: Etodolac, Emulgel, Piperine, Capsaicin, Formulation, Evaluation Download PDF

	Fast reviewing process: Adopting the fast reviewing process we communicate with authors at all stages till publication. Proactive teams of reviewers from National and International front help us to complete the process within the time.
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	Fast reviewing process: Adopting the fast reviewing process we communicate with authors at all stages till publication. Proactive teams of reviewers from National and International front help us to complete the process within the time.
	IJSR dose not impose any publication fee or processing charges.