Indian Journal of Science and Research

Title: COMPARATIVE EVALUATION OF DIFFERENT BRANDS OF LEVOFLOXACIN TABLETS FROM THE LOCAL MARKET
Author: Bivha Dey* and Satish Sahu
Keyword: Levofloxacin, Physicochemical property, In vitro drug release.
Page No: 67-71

Abstract: Levofloxacin a fluoroquinolone antibiotic is widely used for the treatment of various bacterial infections. The different brands of Levofloxacin are available in the market with same dose. Although th e dose is same, the activity of the drug sometimes varies from brand to brand. This may lead to the severe health implications to the patients. Considering the health risk factors and the safety of the patients, the current study has been conducted to examine the various brands of Levofloxacin tablets obtained from the Bilaspur region of the Chhattisgarh state. Methods: Various brands (six brands) of Levofloxacin tablets were collected from the local market of Bilaspur of Chhattisgarh state. The various physicochemical parameters (uniformity of weight, hardness, diameter, thickness, disintegration test) and in vitro drug release study were performed. Results: The various brands of Levofloxacin tablets were collected and evaluated. The weight variation results showed that all the tablets were as per pharmacopoeial standards. The friability study showed that the weight loss was not more than 1% and ranges from 0.4 % to 0.56 %. The hardness of all the brands of Levofloxacin tablets were from 6.56 kg/cm2 to 8.63 kg/cm2. Disintegration times of all the brands were nearly 6 min to 14 min and complied with the pharmacopoeial standards. The in vitro drug release of six brands of Levofloxacin tablets showed that about 90% drugs was released within 30 min in both the pH 1.2 and pH 4.5. Conclusion: The various brands of Levofloxacin tablets were evaluated for its physicochemical properties and in vitro drug release study. The results showed no noticeable changes in the physicochemical properties but remarkable changes were observed in the Levofloxacin release from the various brands of tablets. The results further suggest for the evaluation of antibacterial activity of the different brands of Levofloxacin on a large number of strains. Keywords: Levofloxacin, Physicochemical property, In vitro drug release. Download PDF

Title: COMPARATIVE EVALUATION OF DIFFERENT BRANDS OF LEVOFLOXACIN TABLETS FROM THE LOCAL MARKET
Author: Bivha Dey* and Satish Sahu
Keyword: Levofloxacin, Physicochemical property, In vitro drug release.
Page No: 67-71

Abstract: Levofloxacin a fluoroquinolone antibiotic is widely used for the treatment of various bacterial infections. The different brands of Levofloxacin are available in the market with same dose. Although th e dose is same, the activity of the drug sometimes varies from brand to brand. This may lead to the severe health implications to the patients. Considering the health risk factors and the safety of the patients, the current study has been conducted to examine the various brands of Levofloxacin tablets obtained from the Bilaspur region of the Chhattisgarh state. Methods: Various brands (six brands) of Levofloxacin tablets were collected from the local market of Bilaspur of Chhattisgarh state. The various physicochemical parameters (uniformity of weight, hardness, diameter, thickness, disintegration test) and in vitro drug release study were performed. Results: The various brands of Levofloxacin tablets were collected and evaluated. The weight variation results showed that all the tablets were as per pharmacopoeial standards. The friability study showed that the weight loss was not more than 1% and ranges from 0.4 % to 0.56 %. The hardness of all the brands of Levofloxacin tablets were from 6.56 kg/cm2 to 8.63 kg/cm2. Disintegration times of all the brands were nearly 6 min to 14 min and complied with the pharmacopoeial standards. The in vitro drug release of six brands of Levofloxacin tablets showed that about 90% drugs was released within 30 min in both the pH 1.2 and pH 4.5. Conclusion: The various brands of Levofloxacin tablets were evaluated for its physicochemical properties and in vitro drug release study. The results showed no noticeable changes in the physicochemical properties but remarkable changes were observed in the Levofloxacin release from the various brands of tablets. The results further suggest for the evaluation of antibacterial activity of the different brands of Levofloxacin on a large number of strains. Keywords: Levofloxacin, Physicochemical property, In vitro drug release. Download PDF

Title: HIGH PERFORMANCE LIQUID CHROMATOGRAPHY SEPARATION AND QUANTITATION OF CONVENTIONAL UNANI FORMULATIONS
Author: G. Pavan Kumar* and Neeraj K. Sharma
Keyword: Unani Medicine, Conventional Drugs, Polyherbal Formulation, HPLC–PDA, Quality control of Herbal Drugs.
Page No: 72-77

Abstract: For the simultaneous quantitative determination of nine bioactive compounds, including four phenolic (gallic acid, ellagic acid, chebulinic acid, and tannic acid), two flavanoids (rutin and quercetin) , two anthraquinones (sennoside A and B), and one oxygenated hydrocarbon (vitamin C), a new High Performance Liquid Chromatography-Photodiode Array Detector (HPLC-PDA) method has been Gradient elution was used to separate the samples on a C18 LiChrospher 100 column (5 mm, 250 3 4.6 mm), and the results were recorded at 254 nm. The findings showed that the suggested method is reliable, precise, cost-effective, and appropriate for quality control of conventional polyherbal Unani formulations incorporating complex chemicals with various structures, such as Itrifals. Keywords: Unani Medicine, Conventional Drugs, Polyherbal Formulation, HPLC–PDA, Quality control of Herbal Drugs. Download PDF

Title: HIGH PERFORMANCE LIQUID CHROMATOGRAPHY SEPARATION AND QUANTITATION OF CONVENTIONAL UNANI FORMULATIONS
Author: G. Pavan Kumar* and Neeraj K. Sharma
Keyword: Unani Medicine, Conventional Drugs, Polyherbal Formulation, HPLC–PDA, Quality control of Herbal Drugs.
Page No: 72-77

Abstract: For the simultaneous quantitative determination of nine bioactive compounds, including four phenolic (gallic acid, ellagic acid, chebulinic acid, and tannic acid), two flavanoids (rutin and quercetin) , two anthraquinones (sennoside A and B), and one oxygenated hydrocarbon (vitamin C), a new High Performance Liquid Chromatography-Photodiode Array Detector (HPLC-PDA) method has been Gradient elution was used to separate the samples on a C18 LiChrospher 100 column (5 mm, 250 3 4.6 mm), and the results were recorded at 254 nm. The findings showed that the suggested method is reliable, precise, cost-effective, and appropriate for quality control of conventional polyherbal Unani formulations incorporating complex chemicals with various structures, such as Itrifals. Keywords: Unani Medicine, Conventional Drugs, Polyherbal Formulation, HPLC–PDA, Quality control of Herbal Drugs. Download PDF

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	Fast reviewing process: Adopting the fast reviewing process we communicate with authors at all stages till publication. Proactive teams of reviewers from National and International front help us to complete the process within the time.
	IJSR dose not impose any publication fee or processing charges.