Indian Journal of Science and Research

Title: QUANTIFICATION OF EUGENOL (FROM CLOVE OIL) IN MARKETED HERBAL TOOTHPASTE PRODUCTS
Author: Ashutosh Jadhav* and Akshay Charegaonkar
Keyword: Eugenol, Clove oil, herbal toothpaste, High performance thin layer chromatography/ HPTLC, anti-inflammatory, antioxidant, antimicrobial, traditional medicine, oral hygiene.
Page No: 77-80

Abstract: A straightforward and accurate HPTLC (high-performance thin-layer chromatographic) approach has been created and validated for the quantification of eugenol in commercial toothpaste samples. Using tol uene-ethyl acetate (97:3) as the mobile phase, chromatographic separation was performed on pre-coated silica gel F254 HPTLC plates along with standard eugenol. The UV absorbance spectrum of eugenol indicated 281 nm as its lambda max and hence this wavelength was used for quantification. Linearity, precision, selectivity, limit of detection, limit of quantification, and accuracy of the method were all validated as per ICH Q2R1 guidelines. A correlation coefficient of 0.9967 was obtained from linear calibration curve in the 2 to 14 µg/band range. The relative standard deviations for the intra-day (n = 8) and inter-day (n = 8) precision, respectively, ranged from 1.78% to 2.34% and from 1.78% to 2.11%. The limits of detection and quantification were found to be 2.156 g band-1 and 4.581 g band-1, respectively. The accuracy from real life samples was determined to be 97.00% when expressed as a percentage of recovery. The method was specific and did not exhibit matrix interference. This is an affordable, easy to use, reliable method and suitable for use by QC and regulatory labs. Keywords: Eugenol, Clove oil, herbal toothpaste, High performance thin layer chromatography/ HPTLC, anti-inflammatory, antioxidant, antimicrobial, traditional medicine, oral hygiene. Download PDF

Title: QUANTIFICATION OF EUGENOL (FROM CLOVE OIL) IN MARKETED HERBAL TOOTHPASTE PRODUCTS
Author: Ashutosh Jadhav* and Akshay Charegaonkar
Keyword: Eugenol, Clove oil, herbal toothpaste, High performance thin layer chromatography/ HPTLC, anti-inflammatory, antioxidant, antimicrobial, traditional medicine, oral hygiene.
Page No: 77-80

Abstract: A straightforward and accurate HPTLC (high-performance thin-layer chromatographic) approach has been created and validated for the quantification of eugenol in commercial toothpaste samples. Using tol uene-ethyl acetate (97:3) as the mobile phase, chromatographic separation was performed on pre-coated silica gel F254 HPTLC plates along with standard eugenol. The UV absorbance spectrum of eugenol indicated 281 nm as its lambda max and hence this wavelength was used for quantification. Linearity, precision, selectivity, limit of detection, limit of quantification, and accuracy of the method were all validated as per ICH Q2R1 guidelines. A correlation coefficient of 0.9967 was obtained from linear calibration curve in the 2 to 14 µg/band range. The relative standard deviations for the intra-day (n = 8) and inter-day (n = 8) precision, respectively, ranged from 1.78% to 2.34% and from 1.78% to 2.11%. The limits of detection and quantification were found to be 2.156 g band-1 and 4.581 g band-1, respectively. The accuracy from real life samples was determined to be 97.00% when expressed as a percentage of recovery. The method was specific and did not exhibit matrix interference. This is an affordable, easy to use, reliable method and suitable for use by QC and regulatory labs. Keywords: Eugenol, Clove oil, herbal toothpaste, High performance thin layer chromatography/ HPTLC, anti-inflammatory, antioxidant, antimicrobial, traditional medicine, oral hygiene. Download PDF

Title: EVALUATION OF ANTICONVULSANT PROPERTIES OF LEUCAS ASPERA AERIAL PARTS ON EXPERIMENTAL RODENTS
Author: Shambhulingaiah H M * Anjali K, Darshan Gouda, K. Choudamma, Karthik Kumar, Vijayalaxmi M
Keyword: Anticonvulsant, Leucas aspera, indigenous system, soxhlet Extraction, Phytochemicals, medicinal plants
Page No: 81-86

Abstract: Epilepsy is the most common disorder the Brain or Neurological symptom, affecting more than 50 million people worldwide, caused by sudden abnormal and recurrent electric discharge from the affected brain cells, the present investigation has been undertaken to study the anticonvulsant property of 95% Ethanolic extract of aerial part of Leucas aspera. The Phyto constituents are extracted by using continuous extraction method in soxhlet Extractor with solvents like petroleum Ether & 95% Ethanol. By executing the Qualitative & Quantitative Analysis we found and conformed that the Phytochemicals like flavonoids, terpinoids, saponins, carbohydrates, proteins etc are present, The anticonvulsant activity of the Leucas aspera was estimated by PTZ (Pentylenetetrazole) induced convulsion and Maximal electro shock induced convulsion models in experimental rodents, From the studies it is concluded that 95% ethanolic extract of aerial parts of Leucas aspera shows anticonvulsant property, by reducing the convulsive phase and mortality. Keywords: Anticonvulsant, Leucas aspera, indigenous system, soxhlet Extraction, Phytochemicals, medicinal plants Download PDF

Title: EVALUATION OF ANTICONVULSANT PROPERTIES OF LEUCAS ASPERA AERIAL PARTS ON EXPERIMENTAL RODENTS
Author: Shambhulingaiah H M * Anjali K, Darshan Gouda, K. Choudamma, Karthik Kumar, Vijayalaxmi M
Keyword: Anticonvulsant, Leucas aspera, indigenous system, soxhlet Extraction, Phytochemicals, medicinal plants
Page No: 81-86

Abstract: Epilepsy is the most common disorder the Brain or Neurological symptom, affecting more than 50 million people worldwide, caused by sudden abnormal and recurrent electric discharge from the affected brain cells, the present investigation has been undertaken to study the anticonvulsant property of 95% Ethanolic extract of aerial part of Leucas aspera. The Phyto constituents are extracted by using continuous extraction method in soxhlet Extractor with solvents like petroleum Ether & 95% Ethanol. By executing the Qualitative & Quantitative Analysis we found and conformed that the Phytochemicals like flavonoids, terpinoids, saponins, carbohydrates, proteins etc are present, The anticonvulsant activity of the Leucas aspera was estimated by PTZ (Pentylenetetrazole) induced convulsion and Maximal electro shock induced convulsion models in experimental rodents, From the studies it is concluded that 95% ethanolic extract of aerial parts of Leucas aspera shows anticonvulsant property, by reducing the convulsive phase and mortality. Keywords: Anticonvulsant, Leucas aspera, indigenous system, soxhlet Extraction, Phytochemicals, medicinal plants Download PDF

Title: FORMULATION DEVELOPMENT AND EVALUATION OF MICONAZOLE NITRATE EMULGEL
Author: Rahul Parmar, Neeraj Sharma, Dharmendra Solanki, Umesh Atneria
Keyword: Emulgel, phytochemicals,
Page No: 87-92

Abstract: Topical Emulgel containing Miconazole Nitrate can be used in treatment of many skin infections such Jock Itch, Athlete’s Foot, Ring worm and Tinea Versi color. This hydrophobic drug was incorporated t o emulgel for application to skin. Stable emulgel was formulated in terms of physically and chemically stability, for drug delivery. Experimental designs are used for the selection of optimized batch. Formulation was evaluated for viscosity, % Drug content, % Drug release, Spreadability and pH. Keywords: Emulgel, phytochemicals. Download PDF

Title: FORMULATION DEVELOPMENT AND EVALUATION OF MICONAZOLE NITRATE EMULGEL
Author: Rahul Parmar, Neeraj Sharma, Dharmendra Solanki, Umesh Atneria
Keyword: Emulgel, phytochemicals,
Page No: 87-92

Abstract: Topical Emulgel containing Miconazole Nitrate can be used in treatment of many skin infections such Jock Itch, Athlete’s Foot, Ring worm and Tinea Versi color. This hydrophobic drug was incorporated t o emulgel for application to skin. Stable emulgel was formulated in terms of physically and chemically stability, for drug delivery. Experimental designs are used for the selection of optimized batch. Formulation was evaluated for viscosity, % Drug content, % Drug release, Spreadability and pH. Keywords: Emulgel, phytochemicals. Download PDF

Title: SUSTAINABLE MANUFACTURING SYSTEMS: OPTIMIZING RESOURCE EFFICIENCY AND MINIMIZING ENVIRONMENTAL IMPACT
Author: Dr Dharmendra Kr Dubey, Dr Savita Agarwal, Amit Kumar Yadav, Mithilesh Kr Singh, Sarvesh Kr Singh
Keyword: Sustainable Manufacturing, Environmental Impact, Optimizing Resources
Page No: 93-97

Abstract: The integration of sustainability into manufacturing systems is imperative to address the growing environmental concerns and regulatory pressures. This research focuses on "Sustainable Manufacturing S ystems: Optimizing Resource Efficiency and Minimizing Environmental Impact," aiming to explore the intersection of industrial engineering and environmental sustainability. By integrating lean and green manufacturing principles, this study seeks to develop comprehensive models that enhance resource efficiency while minimizing ecological footprints. Key aspects include the application of Life Cycle Assessment (LCA) to evaluate environmental impacts across product life cycles, the implementation of energy management systems to reduce consumption and emissions, and the exploration of circular economy practices to promote resource reuse and waste minimization. Advanced manufacturing technologies such as additive manufacturing, IoT, and AI are assessed for their potential to support sustainable practices. Additionally, the study examines the design of sustainable supply chains and the role of industrial symbiosis and eco-industrial parks in fostering collaborative resource optimization. The research employs quantitative analysis, case studies, and experimental methods to identify best practices and develop frameworks for sustainable manufacturing. The expected outcomes include guidelines for industry implementation, insights into the barriers and enablers of sustainability integration, and an enhanced understanding of the balance between economic performance and environmental stewardship. This research is crucial for industries aiming to meet sustainability goals while maintaining competitiveness in a rapidly evolving market landscape. Keywords: Sustainable Manufacturing, Environmental Impact, Optimizing Resources Download PDF

Title: SUSTAINABLE MANUFACTURING SYSTEMS: OPTIMIZING RESOURCE EFFICIENCY AND MINIMIZING ENVIRONMENTAL IMPACT
Author: Dr Dharmendra Kr Dubey, Dr Savita Agarwal, Amit Kumar Yadav, Mithilesh Kr Singh, Sarvesh Kr Singh
Keyword: Sustainable Manufacturing, Environmental Impact, Optimizing Resources
Page No: 93-97

Abstract: The integration of sustainability into manufacturing systems is imperative to address the growing environmental concerns and regulatory pressures. This research focuses on "Sustainable Manufacturing S ystems: Optimizing Resource Efficiency and Minimizing Environmental Impact," aiming to explore the intersection of industrial engineering and environmental sustainability. By integrating lean and green manufacturing principles, this study seeks to develop comprehensive models that enhance resource efficiency while minimizing ecological footprints. Key aspects include the application of Life Cycle Assessment (LCA) to evaluate environmental impacts across product life cycles, the implementation of energy management systems to reduce consumption and emissions, and the exploration of circular economy practices to promote resource reuse and waste minimization. Advanced manufacturing technologies such as additive manufacturing, IoT, and AI are assessed for their potential to support sustainable practices. Additionally, the study examines the design of sustainable supply chains and the role of industrial symbiosis and eco-industrial parks in fostering collaborative resource optimization. The research employs quantitative analysis, case studies, and experimental methods to identify best practices and develop frameworks for sustainable manufacturing. The expected outcomes include guidelines for industry implementation, insights into the barriers and enablers of sustainability integration, and an enhanced understanding of the balance between economic performance and environmental stewardship. This research is crucial for industries aiming to meet sustainability goals while maintaining competitiveness in a rapidly evolving market landscape. Keywords: Sustainable Manufacturing, Environmental Impact, Optimizing Resources Download PDF

	Fast reviewing process: Adopting the fast reviewing process we communicate with authors at all stages till publication. Proactive teams of reviewers from National and International front help us to complete the process within the time.
	IJSR dose not impose any publication fee or processing charges.
	Fast reviewing process: Adopting the fast reviewing process we communicate with authors at all stages till publication. Proactive teams of reviewers from National and International front help us to complete the process within the time.
	IJSR dose not impose any publication fee or processing charges.